Zinc Metabolism: A Review with Regard to Zn Finger Proteins, DNA Methylation and p53; In Reference to its Deficiency Syndromes and Tracing its Immunological as Well as Epigenetic Relations

Epigenetics is the branch of biology that studies effects environment on genetics and vice versa. It connecting link between genotype phenotype an individual, can be widely influenced by nutrition availability certain essential micronutrients, in this review, zinc. Although a trace element, zinc to body as core component more than 300 proteins enzymes, which when functioning normally impart structural mechanical capacities tissues fluids. Zinc ubiquitous all parts regulates various metabolic biological processes such cell proliferation, apoptosis, tumorigenesis, along with regular working fetal adult organs. The role zinc-finger crucial stability protein’s folds turn render it functional play its gene expression serve oncogenes or tumor suppressor genes. deficiency common occurrence world generally due inadequate intake through diet but may also manifest itself inheritable form. low cellular level seen diminishing immunity, increased oxidative stress, reduced functionality p53 protein leading formation, incorrect DNA methylation. While phenotypically, deficit both congenital acquired. Some diseases discussed here are irritable bowel syndrome, acrodermatitis enteropathica, thymic atrophy, celiac disease preterm birth. In focus aspect cells epigenetic modulator/regulator subsequent consequences arising imbalance cell.